لأن عملها الرئيسي هو تغذيةخلايا النطاف المتطورة عبر مراحلالتطور المنوي للنطاف, فإن خلايا سيرتولي تدعى أيضا بالخلاياالأم أو الحاضنة(fghh). خلايا سيرتولي تعمل أيضا كخلايا بلعمية, مستهلكة السايتوبلازما(الهيولى) المتبقية خلال عملية تكوين النطاف, نقل الخلايا الجرثومية من قاعدة الأنابيب المنوية إلى تجويف الأنابيب المنوية يحدث بواسطة تغيرات تشكيلية في الأطراف الهامشية الجانبية لخلايا سيرتولي.
> cite journal author Xiong X, Wang A, Liu G, Liu H, Wang C, Xia T, Chen X, Yang K Effects of p,p'-dichlorodiphenyldichloroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells journal Environ Res volume 101 issue 3 pages 334–9 year pmid 16380112 doi 10.1016/j.envres.2005.11.003
The tight junctions of Sertoli cells form the blood-testis barrier , a structure that partitions the interstitial blood compartment of the testis from the adluminal compartment of the s iniferous tubules. Because of the apical progression of the spermatogonia, the tight junctions must be dynamically reformed and broken to allow the immunoidentical spermatogonia to cross through the blood-testis barrier so they can become immunologically unique. Sertoli cells control the entry and exit of nutrient s, hormone s and other ch icals into the tubules of the testis as well as make the adluminal compartment an immune-privileged site.
The cell is also responsible for establishing and maintaining the spermatogonial st cell niche, which ensures the renewal of st cells and the differentiation of Spermatogonium spermatogonia into mature germ cells that progress stepwise through the long process of spermatogenesis, ending in the release of Spermatozoon spermatozoa . Sertoli cells bind to spermatogonial cells via N-cadherins and galctosyltransferase (via carbohydrate residues).
Sertoli cells are called so because of their eponym Enrico Sertoli , an Italian physiologist who discovered th while studying medicine in the University of Pavia, Italy. WhoNamedIt synd 518
He published a description of this cell in 1865. The cell was discovered by Sertoli with a Belthle microscope purchased in 1862, which he used while studying medicine.
In the 1865 publication, his first description used the terms tree-like cell or stringy cell and most importantly he referred to these mother cells. It was other scientists who used Enrico's family name, Sertoli, to label these cell in publications, starting in 1888. As of , two textbooks that are devoted specifically to the Sertoli cell have been published.
On slides, using standard staining, it can be easy to confuse the Sertoli cells with the other cells of the germinal epithelium. The most distinctive feature of the Sertoli cells is the dark nucleolus .OSU Center for Veterinary Health Sciences - OSU-CVHS Home